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But one by one, each of those antibiotics - and almost every new one that has come along since - eventually stopped working. One reason is that the bacterium that causes gonorrhea can mutate quickly to defend itself, Zenilman said. It got to the point recently where doctors had only two antibiotics left that still worked well against gonorrhea - cefixime and ceftriaxone.
Cefixime and ceftriaxone are in the same class of antibiotics. Totally untreatable gonorrhea is popping up in Asia and Europe.